OUR PLATFORM

WE ARE DEVELOPING A PORTFOLIO OF NOVEL NON-OPIOID THERAPEUTICS THAT PROVIDE LONG-LASTING PAIN RELIEF AFTER A SINGLE LOCAL ADMINISTRATION.

Concentric has an extensive IP portfolio, including a USPTO-issued composition of matter patent, that provides extended commercial exclusivity.

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Our lead investigational product candidate, CA-008, is a water-soluble prodrug that converts into capsaicin – the naturally occurring molecule that gives chili peppers their heat and is a potent TRPV-1 agonist.

Capsaicin, which has a long history of use as a topical analgesic, selectively and reversibly desensitizes pain conducting nerve fibers (C-fiber nociceptors).

TRPV-1 agonism evokes an initial neuronal excitation that is followed by a durable refractory state to provide long lasting analgesia.


ATTRIBUTES OF OUR PRO-DRUG PLATFORM

REALIZING THE "HOLY GRAIL" OF PAIN MANAGEMENT

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Non-opioid
 - Reduced opioid consumption & opioid-related AE's
Site-specific
 - Targets pain at source with limited systematic exposure
Simple
 - Single injection
 - Simplifies ongoing care & adherence
Long-lasting
 - Continuous and extended relief
Pain-selective
 - Extended pain relief without numbness or weakness