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Overview


Novel TRPV1 Agonist Prodrugs for Pain

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Overview


Novel TRPV1 Agonist Prodrugs for Pain

We are developing a portfolio of novel, non-opioid therapeutics that provide long-lasting pain relief after a single local administration.

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Attributes


Attributes of our prodrugs

Attributes


Attributes of our prodrugs

Reduced opioid consumption & opioid-related AE's

NON-OPIOID


Targets pain at source with limited systematic exposure

SITE SPECIFIC


Single injection simplifies ongoing care & adherence

SIMPLE


Continuous and durable relief

LONG LASTING


PAIN-SELECTIVE

Extended pain relief without numbness or weakness

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The Problem


The Problem

 

The Problem


The Problem

 

Current Postsurgical Treatment Options Fall Short

THERE IS NO "GOOD" WAY TO PROVIDE CONTINUOUS, EFFECTIVE PAIN RELIEF BEYOND THE FIRST 18-24 HOURS AFTER SURGERY.

  • Treating pain systemically with opioids (e.g. Vicodin®, morphine) provides relief but dramatically increases costs and morbidity
  • Treating pain at its source with local anesthetic is highly effective yet limited as a result of its short duration of action
  • Treating pain with conduction blocks is highly effective, but clinically cumbersome and costly

Despite Advances In Cancer Treatment, Cancer Pain Continues To Be A Problem With A Heavy Reliance On Opioids

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  • Pain is the most feared symptom with cancer (Jain 2015)
  • Despite active cancer treatment
  • Pain prevalence is 33% (more than 75% with advanced disease) (Paice 2011)
  • Severe pain prevalence is 5% (increases with advanced disease) and predicts near-term hospitalizations (Wagner-Johnston 2010)
  • Opioids, while the mainstay of treatment, are limited by side effects
  • Eventually, conservative treatments fail and require invasive approaches which are costly
  • The annual cost of cancer pain is $243 B (Gaskin 2012) 
     

There Are Few Durable, Effective and Safe Treatment Options For Moderate To Severe Osteoarthritis (OA) Pain

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THERE IS NO “GOOD” WAY TO PROVIDE DURABLE, EFFECTIVE RELIEF FOR MODERATE TO SEVERE OSTEOARTHRITIS PAIN.

  • NSAIDS only effective for mild-to-moderate and have significant safety issues (GI, Renal, CV)
  • Opioids provide relief but dramatically increase costs and morbidity
  • Intra-articular steroids ("IA") are somewhat effective yet limited due to short duration of action
  • IA hyaluronic acid has limited differentiation from placebo in controlled clinical studies
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Goal


Goal

 

Goal


Goal

 

Our goal is to drive the actualization of value-based health care by substantially reducing costs, improving outcomes and reducing intensivity of care.

 
  • DECREASE OPIOID USE AND HARMFUL, COSTLY SEQUELAE

  • INCREASE PATIENT SATISFACTION (HCAHPS)

  • SUPERIOR PATIENT-REPORTED OUTCOMES VERSUS STANDARD OF CARE

  • IMPROVE FUNCTIONAL OUTCOMES

  • REDUCE LOST-DAYS-OF-WORK AND HASTEN RETURN TO PRODUCTIVITY

  • REDUCE UNNECESSARY HOSPITAL COSTS INCLUDING: DECREASE TIME TO DISCHARGE AND DECREASE ER VISITS AND RE-ADMITTANCE