Our Platform

We are developing a portfolio of novel non-opioid therapeutics that provide long-lasting pain relief after a single local administration.

Concentric has an extensive IP portfolio, including a USPTO-issued composition of matter patent, that provides extended commercial exclusivity.

Attributes2.png

Our lead investigational product candidate, CA-008, is a water-soluble prodrug that converts into capsaicin – the naturally occurring molecule that gives chili peppers their heat and is a potent TRPV-1 agonist.

Capsaicin, which has a long history of use as a topical analgesic, selectively and reversibly desensitizes pain conducting nerve fibers (C-fiber nociceptors).

TRPV-1 agonism evokes an initial neuronal excitation that is followed by a durable refractory state to provide long lasting analgesia.


ATTRIBUTES OF OUR PRO-DRUG PLATFORM

Realizing The "Holy Grail" of Pain Management

Pain-management.png

Non-opioid
 - Reduced opioid consumption & opioid-related AE's
Site-specific
 - Targets pain at source with limited systematic exposure
Simple
 - Single injection
 - Simplifies ongoing care & adherence
Long-lasting
 - Continuous and extended relief
Pain-selective
 - Extended pain relief without numbness or weakness