March 30, 2022
Concentric Analgesics, Inc., a clinical-stage biopharmaceutical company focused on developing and commercializing novel, non-opioid pain therapeutics, today announced positive results from its recently completed pilot Phase 2 clinical trial of vocacapsaicin in patients undergoing open laparotomy for ventral hernia repair. Vocacapsaicin is a first-in-class, non-opioid, long-lasting therapeutic with FDA Breakthrough Therapy Designation that is administered as a single dose during surgery. The primary objectives of the study, conducted in 24 patients, were to evaluate the effects of vocacapsaicin over 7 days on reported pain with activity, pain at rest, and opioid consumption, as well as safety and pharmacokinetics.
February 2, 2022
Concentric Analgesics, Inc. today announced two important Phase 3 clinical relationships for its lead product candidate, vocacapsaicin.
First, the company has entered into a formal agreement with Evolution Research Group (ERG), a leading postsurgical pain clinical research site network in the U.S., to conduct its registration trials.
“Following our experience with vocacapsaicin in the Phase 2 studies, we are excited for the potential to reproduce these efficacy and safety results in the Phase 3 studies,” said Harold Minkowitz, M.D., president of Analgesics, Perioperative & Hospital Based Research at the HD Research LLC, an Evolution Research Group portfolio company.
January 26, 2022
“We are pleased to announce the closing of this oversubscribed financing, which enables us to continue to advance vocacapsaicin into Phase 3 development and serves as an important first step towards fully funding the program through NDA submission,” said Frank Bellizzi, DMD, Chief Executive Officer of Concentric Analgesics. “We are especially gratified for the continued strong support from leading healthcare investors who share our vision and determination to establish a new, non-opioid, standard of care for the treatment of postsurgical pain.”
November 22, 2021
Concentric Analgesics, Inc. today announced the poster presentation of clinical data for vocacapsaicin, its first-in-class non-opioid lead product candidate for the management of postsurgical pain, at the 2021 American Academy of Hip and Knee Surgeons (“AAHKS”) Annual Meeting in November in Dallas, Texas.
May 11, 2021
Concentric Analgesics, Inc. today announced the podium presentation of clinical data for vocacapsaicin, its first-in-class non-opioid lead product candidate for the management of postsurgical pain, at the 46th Annual Regional Anesthesiology and Acute Pain Medicine (ASRA) Meeting on May 13, 2021 in Orlando, Florida.
This will be the first scientific presentation of the positive results from the recently completed Phase 2 clinical trial in patients undergoing total knee arthroplasty (“TKA”).
January 26, 2021
Concentric Analgesics, Inc., a clinical-stage biopharmaceutical company focused on developing and commercializing novel, non-opioid pain therapeutics, today announced positive topline results from its recently completed Phase 2 clinical trial of vocacapsaicin (CA-008), a first-in-class, non-opioid therapeutic with FDA Breakthrough Therapy Designation. The primary objectives of the study, conducted in 187 patients undergoing total knee arthroplasty (“TKA”), were to evaluate the effects on reported pain, opioid consumption, safety and pharmacokinetics of vocacapsaicin over 7 days.
December 16, 2020
Concentric Analgesics, Inc., a clinical-stage biopharmaceutical company focused on developing and commercializing novel, non-opioid pain therapeutics, today announced positive topline results from its recently completed Phase 2 clinical trial of vocacapsaicin (CA-008), a first-in-class, non-opioid therapeutic with FDA Breakthrough Therapy Designation. The primary objectives of the study, conducted in 187 patients undergoing total knee arthroplasty (“TKA”), were to evaluate the effects on reported pain, opioid consumption, safety and pharmacokinetics of vocacapsaicin over 7 days.
May 21, 2019
Concentric Analgesics, Inc., a clinical-stage biopharmaceutical company focused on developing and commercializing novel, non-opioid pain therapeutics, today announced the successful completion of a $76 million Series B financing. The financing was led by Oracle Investment Management and included additional new investors Venrock Healthcare Capital Partners, Cowen Healthcare Investments, and Kern Whelan Capital.
March 4, 2019
Concentric Analgesics, Inc., a clinical-stage biopharmaceutical company focused on developing and commercializing novel, non-opioid pain therapeutics, today announced that Frank J. Bellizzi, DMD, Chief Executive Officer of Concentric Analgesics, will present at the Cowen 39th Annual Healthcare Conference on Monday, March 11, 2019 at 2:00 pm ET at the Boston Marriott Copley Place.
November 8, 2018
Concentric Analgesics, Inc., a clinical-stage biopharmaceutical company focused on developing and commercializing novel, non-opioid pain therapeutics, today announced positive topline results from its Phase 2 clinical trial of CA-008, a first-in-class, non-opioid therapeutic. The primary objective of the study, conducted in patients undergoing bunionectomy, was to demonstrate the efficacy of CA-008 over 96 hours, with secondary endpoints in opioid consumption, safety and pharmacokinetics.
September 11, 2018
Concentric Analgesics, Inc., a clinical-stage biopharmaceutical company focused on developing and commercializing novel, non-opioid pain therapeutics, announced today that it has received Breakthrough Therapy designation from the U.S. Food and Drug Administration (FDA) for CA-008 in post-surgical pain. CA-008 is a first-in-class non-opioid therapeutic that rapidly converts to capsaicin, a potent TRPV1-agonist. CA-008 provides long-lasting pain relief after a single, local injection by selectively desensitizing pain-conducting nerve fibers, without producing numbness or weakness.
July 16, 2018
Concentric Analgesics, Inc., a clinical-stage biopharmaceutical pain company, announced today that it has initiated a Phase 2 clinical study of CA-008, the Company’s lead product candidate for the treatment of post-surgical pain. CA-008 is a water-soluble non-opioid prodrug that rapidly converts to capsaicin, a potent TRPV1-agonist which selectively desensitizes pain conducting nerve fibers to provide long-lasting analgesia.
May 14, 2018
Concentric Analgesics, Inc., a clinical-stage biopharmaceutical pain company, today announced topline results from its Phase 1b clinical trial for CA-008 in post-surgical pain. The primary objective of the clinical study was to demonstrate the safety and pharmacokinetics of CA-008, with secondary endpoints including efficacy. The study showed that CA-008, a novel, non-opioid therapeutic, was well tolerated at all dose levels compared to the control group following surgery in bunionectomy patients. Although the study was not powered for efficacy, the highest dose cohort of CA-008 showed statistically significant and clinically meaningful (greater than 50%) reductions in area under the curve (AUC) for pain intensity compared to the control group lasting up to 168 hours.
Apr 3, 2018
Concentric Analgesics, Inc., a clinical-stage biopharmaceutical pain company, announced today that it has appointed Susan Kramer, DrPH, Executive Vice President, Program Management & Strategy and Mike A. Royal, MD, Chief Medical Officer. Drs. Kramer and Royal collectively bring more than 50 years of senior biopharmaceutical development experience leading multiple first-in-class therapeutics through market approval.
Dec 7, 2017
Concentric Analgesics, Inc., a clinical-stage biopharmaceutical pain company, announced today that the U.S. Food and Drug Administration (FDA) has granted Fast Track Designation to CA-008 for the treatment of post-surgical pain. CA-008 is a proprietary water-soluble prodrug that converts into capsaicin, a potent TRPV-1 agonist.
Fast Track is a designation by the FDA designed to facilitate the development and expedite the review of drugs which treat serious or life-threatening conditions and fill an unmet medical need. Its purpose is to get important new therapeutics to the patient earlier. Recipients receive an enhanced level of interaction and support from the FDA and there is a strong historical correlation between Fast Track designation and receiving priority review after filing an NDA.
Nov 2, 2017
Concentric Analgesics, Inc., a clinical-stage biopharmaceutical pain company, announced today that it has initiated a Phase 1b clinical trial with CA-008, a proprietary water-soluble prodrug that converts into capsaicin, a potent TRPV-1 agonist. Results from this clinical trial are expected in the first quarter of 2018.
The Phase 1b study is a randomized, double-blind clinical trial, targeting approximately 32
patients undergoing bunionectomy. The goal of the single, ascending-dose trial is to examine the safety, tolerability and pharmacokinetics of CA-008.
Oct. 17, 2017
Concentric Analgesics, Inc., a development-stage biopharmaceutical pain company, announced today that it has appointed Thomas B. King to its Board of Directors. Mr. King brings nearly 40 years of leadership experience building, operating and selling multiple biopharmaceutical businesses.
“Tom brings significant strategic development, regulatory and commercialization experience to the Concentric Analgesics board, which will be valuable as we advance our lead program, CA-008, in post-surgical pain to the clinic, and look to commence IND-enabling studies for CA-011, our osteoarthritis pain program,” said John Donovan, M.D., Chief Executive Officer of Concentric Analgesics. “We are thrilled to have Tom join the Concentric team, particularly at such a transformative time for the company.”
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